Arriving in Lystra, the disciples go to work preaching the Gospel. Paul, in the midst of his sermon discerns a man in the congregation who has faith to be healed from a lifelong handicap. This results in his healing, but witnesses attempted to worship Paul and Barnabas, but they insisted against such worshiped. Satan failed to corrupt the church with false worship, then stirred the Jews from Antioch and Iconium to come to Lystra, instigating the Gentiles to stone Paul to death. But Paul recovered, determined to resist Satan, went back into the city, then headed to another city, determined to preach Christ.

Those who opposed the gospel in Antioch Pisidia expelled Paul and Barnabas from their city. The two arrived in Iconium, some 80 miles west. There they made new converts to Christ amongst the Jews and Gentiles. Then, it was discovered that those opposed to the gospel in Iconium plotted violence against Paul and Barnabas so they fled to Lystra. But the opposition was tireless and will follow them there too.